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Although IAA, IPA, and IBA were able to engage in favorable noncovalent interactions (primarily hydrogen-bonding and electrostatic interactions) with key amino acid residues from the G- and H-subsites of hp GSTP1-1, these interactions were limited in extent and are indicative of low-affinity binding

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Am J Trop Med Hyg (2021) 105:7380

The destruction of the mitochondria may indeed be an early step in the pathology, eventually leading to -cell death and a reduction in the number of functioning -cells

Esler WP, Bence KK