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Statements Author contributions BP conceptualized and wrote the review and prepared the figures

Since superoxide anion cannot diffuse across the inner mitochondrial membrane it remains in the matrix which allows it to react with Fe-S groups in mitochondrial proteins resulting in the liberation of ferrous (Fe 2+ ) iron

De Godoy, I., Donahoe, M., Calhoun, W

Mature cells from donor islets exhibited augmented GSIS though glucose responsive metabolism into PPP, PSP and ABP pathways

Arachidonate 12-lipoxygenase (ALOX12) inactivation diminishes p53-mediated ferroptosis induced by ROS stress ( N1 -acetyltransferase 1 (SAT1) is a transcription target of p53, SAT1 expression induces lipid peroxidation and sensitizes cells to undergo ferroptosis upon ROS-induced stress, while knockout of SAT1 expression or pharmacologically inhibited ALOX15 partially abrogates p53-mediated ferroptosis (Ou et al., 2016)