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CD38 serves as the primary degrading enzyme for nicotinamide adenine dinucleotide (NAD) in mammalian cells, an essential endogenous antioxidant in mammals

In damaged AMD cells, excessive production of ROS induces mitophagy through a process involving the p62/Nrf2 signaling pathway with this having a central role in AMD pathogenesis (93)

[DOI] [PMC free article] [PubMed] [Google Scholar] 293.Lee J.H., Engler J.A., Collawn J.F., Moore B.A

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Macro- ATG consists in the delivery of cytoplasmic cargo to the lysosome through the intermediary of a double membrane bound vesicle, the autophagosome, which fuses with the lysosome to form an autolysosome (Zhang, 2013)