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Hence, cancer cells are addicted to glutamine ( Macrophages are important immune cells and play a significant role in both innate and adaptive immunity ( Currently, the combined treatment with GLS1 inhibitor CB-839 has entered the clinical trial stage and achieved certain therapeutic effects ( 2 The characterization of glutamine metabolism and macrophage polarization 2.1 The core pathways and regulatory nodes of glutamine metabolism Glutamine traverses the cell membrane via specific transporters (including SLC1A5, SLC38A1/A2, and SLC6A14) to enter the cells