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(Note that homocysteine can also be converted to methionine by the folate-independent enzyme betaine-homocysteine methyltransferase (BHMT).) MTHFR contains a bound flavin cofactor and uses NAD(P)H as the reducing agent

This will not only improve our understanding of ferroptosis and GIME but also provide a new solution for glioma immunotherapy resistance, a new breakthrough point for glioma treatment

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[DOI] [PubMed] [Google Scholar] 116.Warburg O., Wind F., Negelein E

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At the pathological level, excessive oxidative stress induces NPPC apoptosis and senescence [71], while abnormal mechanical loading compromises differentiation capacity and viability [72,73,74]