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doi: 10.3390/cells10081897 301 ZaboliE.MajidiH.Alizadeh-NavaeiR.Hedayatizadeh-OmranA.Asgarian-OmranH.LarijaniL

doi: 10.1001/jamapsychiatry.2023.5371 280 StarrAEDeekeSANingZde NanassyJSingletonRBenchimolEIet al

Sources: The information above is derived from recent scientific literature and studies on MOTS-c, including peer-reviewed research articles and reviews that investigate the peptides functions in metabolism and aging

doi: 10.1007/s00280-015-2723-x

2 Long-term opioid use leads to tolerance (i.e., less susceptibility to the effects of the opioid, which can result in a need for higher and more frequent doses to achieve the same analgesic effect), physical dependence, and opioid-withdrawal symptoms during weaning and contributes to the development of chronic pain later and opioid-induced hyperalgesia (a paradoxical hypersensitivity to pain)

Controversies in regenerative medicine: should intervertebral disc degeneration be treated with mesenchymal stem cells