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IGF-1 signaling influences immune cell development and function in research models, and LR3 has been used to probe these effects without the complicating IGFBP biology that would confound native IGF-1 experiments

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10 The combinatorial regimen of SMART1 and AR12 induces potent tumor suppression in KRAS-mutated CRC

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NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses J Exp Med 1997 185 : 953961 Kontgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, Gerondakis S

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Montesinos P, Recher C, Vives S, et al

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Larger studies are required

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