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Four-drug regimens (quadruplet therapy) are similar to three-drug regimens but also include an anti-CD38 monoclonal antibody (Darzalex or Sarclisa)
L.TianK

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Shin, S.C

These findings are consistent with several studies that have investigated the interconnected nature of NRF2 and NF-B pathways

J Med Chem 60:67216732 Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, Da-Fonseca PC, Winzeler EA, Ng CL, Bogyo M, Fidock DA (2019) Covalent Plasmodium falciparum -selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents