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It is worth mentioning that ebselen does not contribute to the bioavailable selenium pool required for the biosynthesis of selenoproteins including seleno-GPxs and therefore its ability to detoxify hydroperoxides under cellular conditions can exclusively be attributed to GPx mimicking activity [77, 79]

10.1007/978-90-481-3419-9_149 12 BadakhshS.EskandarianT.EsmaeilpourT

A critical oversight in many studies is the assumption that oxidative stress is the primary, or sole, cause of the disease in question

Meanwhile, proteomics elucidates the role of proteins in diseases by analyzing protein structures, providing a basis for drug design (Lee et al., 2011

38 Tested on heme proteins, it showed reliable shifts (0.85 correlation) and matched experimental data, aiding in the understating on ROS biology by advancing the prediction and engineering of redox-active proteins and understanding redox signaling in cellular processes and diseases

Physiol behav 83:699709