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The tendency for general infections and the possibility of diverticulitis are other disadvantages of JAK inhibitors [50]
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Inhibitors targeting enzymes such as adenosine phosphate transferase, non-ribosomal peptide synthase (NRPS), polyketide synthase, and NRPS-independent siderophore synthases impair microbial iron uptake and enhance host-mediated clearance (Petrik et al., 2012
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