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Vitamin B12 occurs naturally in many foods, including meat, fish, and dairy products

[DOI] [PubMed] [Google Scholar] van den Dobbelsteen DJ, Nobel CS, Schlegel J, Cotgreave IA, Orrenius S, Slater AF

10.1111/ijd.15573 Duperray J, Sergheraert R, Chalothorn K, Tachalerdmanee P, Perin F: The effects of the oral supplementation of L-cystine associated with reduced L-glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial

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A repeated-measures two-way ANOVA revealed a significant main effect of the factors treatment (F (1,16) = 12.47, P = 0.0028), time (days) (F (5,80) = 4.437, P = 0.0012), and a significant treatment time interaction (F (5,80) = 10.89, P 0.05

Simpler platforms, such as 2D in vitro cultures, enable rapid, scalable screening with minimal ethical burden, whereas more complex systems, including organoids, provide greater human relevance but introduce challenges in standardization, interpretation and reproducibility 37