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PKA is released from its regulatory subunits, migrates to the nucleus, and phosphorylates CREB at Ser-133

Hazard Prevention and Control GHS labeling - Irritation Firefighting Measures: Wear a self-contained breathing apparatus with full facepiece and pressure-demand or other positive-pressure mode, approved by MSHA/NIOSH (or equivalent), and full protective gear

Once activated, Akt, one of the main downstream targets of mTORC2 [296], induces inhibitory phosphorylation of the positive regulators of autophagy Beclin-1 [297], forkhead box O3 (FoxO3) [257], and glial fibrillary acidic protein (GFAP) [298]
This dietary intervention trial received ethical approval from the Quadram Institute Bioscience Human Research Governance Committee (QIB01/2024) and the South East Scotland Research Ethics Committee (24/SS/0047) and is registered at ClinicalTrials.gov (NCT06518343)