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119 Indeed, the TSC1TSC2 complex contains a GTP (guanosine triphosphate)ase-activating protein domain, which stimulates the GTPase activity of RHEB and thereby preventing it to activate mTORC1

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Importantly, in the patients bearing tumors with NRF2-KEAP1 alteration a significantly increase in expression of NRF2 target genes was observed, such as NQO1, and the enzymes responsible for GSH synthesis, GCLC and GCLM, which indicates that GSH levels are also higher (Fig

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