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Despite all these similarities, the specific amino acid alterations among both enzymes affect the size and the chemistry of the disulfide-substrate-binding sites

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Consequently, multiple research groups launched drug discovery programs targeting GlyT1, giving rise to a highly competitive field marked by structurally diverse chemotypes and a large number of patent filings

Each named dose 2.5, 5, 7.5, 10, 12.5, 15 mg corresponds to a documented step