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The participants were subsequently positioned prone with their feet placed in a fully relaxed state and their ankles hanging freely off the edge of the examination bed

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Adverse Reactions/Side Effects Generalized: Anaphylactic shock and death have been reported with administration of parenteral vitamin B12 (see WARNINGS)

This is indicative of in situ oxidative stress and/or generation of APAPs reactive intermediate and a disruption in brain redox balance sufficient enough to be detected by this oxidative stress sensor (Figure 4)(127)