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This work was supported by a Grant-in-Aid for JSPS Specially Promoted Research (21000005), Platform for Drug Discovery, Informatics and Structural Life Science from MEXT, Japan, and the Life Science Research Fund of Takeda Science Foundation to H.S., a Grant-in-Aid for JSPS Fellows to K.I

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The small molecule compound RSL3 can also bind to the Sec in the active site of GPX4, directly inhibiting the antioxidant activity of GPX4 and inducing ferroptosis (Yang et al., 2014