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In 1977, Beckwith and coworkers reported melanocortin ligands had differential effects on male and female rats [176]

particularly, mutations in SRSF2 , ASXL1 , and RUNX1 were associated with adverse prognosis

Martin, R., Sospedra, M., Eiermann, T

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Nevi at acral sites, especially on the palms and soles, may show discrete columns of melanin pigment in the stratum corneum ( Fig