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Metabolic stress response factors ATF4 and mTORC1 are activated downstream of IFN- production Amongst the IFN-target genes that were identified, many are well-known targets of the ATF4 transcription factor as for example those related to serine, asparagine and GSH metabolism [19]
Nakatomi et al
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Phase I Study of Quizartinib Administered Daily to Patients With Relapsed or Refractory Acute Myeloid Leukemia Irrespective of FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication Status
1,2 The pathological examination revealed disc tissue with central balloon-type cystic degenerative changes (Figure 5)
