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In ALL-derived cell lines and bone marrow mononuclear cells from ALL patients, 7 Wnt antagonists (sFRP1, sFRP2, sFRP4, sFRP5, WIF1, DKK3, and HDPR1) showed abnormal promoter methylation

1,2,6,18 The recommended laboratory evaluation for patients with suspected vitamin B 12 deficiency includes a complete blood count and serum vitamin B 12 level

this effect is prevented by upregulation of Grk2 [58]

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But some symptoms warrant immediate attention

Of the 252 patients, 184 (73%) entered the extension