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16, 17 In addition, in cultured vascular smooth muscle cells (VSMCs) and isolated arteries from hypertensive rats and humans, ROS production is enhanced, redox-dependent signaling is amplified, and antioxidant bioactivity is reduced

These include semi-solids (e.g., ointments and gels), solids (e.g., powders, inserts, and contact lenses), and hybrid systems (e.g., in situ gels), which offer improved drug retention and sustained release profiles

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