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Cadmium exposure dysregulates purine metabolism and homeostasis across the gut-liver axis in a mouse model
B12 is also necessary for metabolic and hormonal function

Other examples for IN application of systemic acting small molecules are analgesics with anti-inflammatory effects such as indomethacin and ketorolac [14]
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In vivo, its metabolites include trichloroacetic acid, proving that it functions as a substrate (Poon et al., 2000) there by being capable of inhibiting the metabolism of other aldehydic substrates of ALDHs
