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Given the prevalence of anxiety and depression in these patients, which ranges from 13 to 80% [118], antidepressants and antiepileptic drugs, which have been shown to be effective in the majority of patients, could also have a positive effect on pain symptoms and could be an indication for pharmacological treatment at the first approach

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However, other psychological symptoms (anxiety, depression, irritability), arousal (drowsiness), neurologic symptoms (photophobia), and cranial parasympathetic symptoms (lacrimation), as well as general symptoms (e.g., yawning, increased urination, nausea, diarrhea, and food cravings), can precede the onset of pain [61,62]

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