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The NRF2-dependent transcriptional regulation of antioxidant defense pathways: relevance for cell type-specific vulnerability to neurodegeneration and therapeutic intervention

Adegbola P, Aderibigbe I, Hammed W, Omotayo T (2017) Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review

Additionally, bypassing the BBB through intranasal routes deserves further exploration

Emerging evidence suggests that Nrf2 can enhance the expression of rhythm-inhibiting genes such as cryptochrome 2 and Rev-Erb in the nucleus, thereby indirectly inhibiting transcription mediated by the CLOCK-BMAL1 complex [103]

Kyowa Hakko Bio pays close attention to further clinical research and development efforts for improving the stability and bioavailability of glutathione for later use in drug and nutraceutical formulations

Furthermore, Aspm (asp (abnormal spindle)-like, microcephaly associated) and anatgonists of the Wnt-signalling cascade, Sfrp-1 (secreted frizzled-related protein) and -2, as well as Sost (sclerostin), are involved in the FoxO-dependent regulation
