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Research on HGF/c-Met signaling in other biological contexts demonstrates receptor internalization beginning around 4872 hours of sustained activation, with maximal downregulation occurring by day 57 of continuous agonist exposure

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(2004) Insulin-like growth factor-I stimulates both cell growth and lipogenesis during differentiation of human mesenchymal stem cells into adipocytes

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doi: 10.1111/imr.12065

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