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The interaction between vitamin B12 and Apolipoprotein E (APOE) significantly influences cognitive function in older adults, with APOE carriers showing a stronger positive association between vitamin B12 levels and cognitive performance compared to noncarriers [61]

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The glutamatergic system of neurons, receptors and transporters are intimately involved in pain but, to date, there have been few drugs developed that therapeutically modulate this system

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Cell 113 , 445456 (2003)

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