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Metal-Polyphenol-Network Coated Prussian Blue Nanoparticles for Synergistic Ferroptosis and Apoptosis via Triggered GPX4 Inhibition and Concurrent In Situ Bleomycin Toxification

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How RXR regulates GCLC and GS remains to be elucidated

In this clinical trial study, oral liposomal glutathione supplementation (L-GSH) or placebo was given to individuals with T2DM to investigate the therapeutic effects of L-GSH supplementation

Upon activation of the intrinsic apoptosis pathway, mitochondria release both cytochrome c and second mitochondria-derived activator of caspase (Smac), also known as DIABLO (direct inhibitor of apoptosis protein-binding protein with low pI) (Fulda, 2015)