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Furthermore, Yang et al

This is a feedback loop with a whole-body reach, and it is a good candidate for a clock mechanism in its own right

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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Navarro-Alarcon M., Cabrera-Vique C

Following mitochondrial permeabilization, pro-apoptotic factors, including cytochrome c, are released into cytosol, leading to the formation of a caspase-activating complex (101,105)

It exhibits a dual role: in low concentrations, it participates in signal transduction, while in high concentrations, it exerts a toxic effect on the cell