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This pattern of expression for TLR4 and TLR9 is inversed in tissue from infants suffering from necrotizing enterocolitis (NEC) and might be of pathophysiological relevance (51)

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[0229] Embodiment 222: A method of expanding a population of genetically engineered T cells in a mammal diagnosed with cancer, said method comprising administering to said mammal administering to said mammal a T cell genetically modified to express a chimeric antigen receptor (CAR) according to any one of embodiments 201- 205, wherein the administered genetically engineered T cell produces a population of progeny T cells in the human