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Br J Cancer 99:527531

Protecting cellular structures from the damage caused by oxidative stress

Studies in human embryonic kidney 293 (HEK 293) cells overexpressing hOAT3 showed that there was an enhanced uptake of MPAG (Uwai et al., 2007), morinidazole glucuronides (Zhong et al., 2014), daidzein-7-O-glucuronide, genistein-7-O-glucuronide, glycitein-7-O-glucuronide and quercetin-3-O-glucuronide (Wong et al., 2011), which suggested that OAT3 contributes to the renal tubular secretion of these glucuronide conjugates

YekelerHBGulerEBeatoPSPriyaSAbobakrFKMDoganMet al

The peptides were fragmented using higher-energy collisional dissociation (HCD) with a normalized collision energy of 28, and fragment ions were detected using an Orbitrap

No adverse effects were noted in clinical trials (ulcerative colitis, phase II), and in toxicological studies, a lethal dose (LD1) could be not achieved (for review see [1,2,3,4,5,6,7,8,9,10,96,97,106,107,193])