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In particular, two RCTs showed the efficacy of PGB compared to placebo on pain and related symptoms in adults [21, 22] and one study in adolescents with FM [20] failed to show a significant improvement in mean pain score

Sun, D.-W

Most carnitine in our bodies is found in our muscles

Use only as directed on the label

[131] indicates that LC supplementation increases plasma concentrations of insulin-like growth factor-1 (IGF-1) and activates the corresponding signaling pathways

We registered this study prospectively in Open Science Framework, Search strategy and study eligibility We searched in four databases (PubMed, Embase, Cochrane Library, and Web of Science) from inception to 1 November 2022 for potentially relevant records without language restrictions (for search terms used, see the Appendix: Text S1)