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A drawback with vesicles, however, is that it is not as straightforward to use the surface analytical tools as it is on planar surfaces, Prof

(Chen et al., 2012) prepared siRNA-LNPs with 90 % gene silencing in vivo using a microfluidic device created using PDMS and soft lithography, where the nucleic acid solution was initially mixed with the lipid solution and subsequently diluted with a buffer solution