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Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies

26 DworkinR

In consequence, acylcarnitines constitute an appreciable component of the tissue carnitine pool, and tissue and plasma concentrations of carnitine and acylcarnitines are together maintained within relatively narrow limits by a variety of mechanisms, which influence in turn innumerable aspects of carbohydrate and lipid metabolism, including the regulation of insulin secretion by pancreatic -cells and the determination of tissue insulin sensitivity

This application originally an incidental finding in early tanning research has been extensively studied and led directly to the development of PT-141 (Bremelanotide) as a selective MC4R-targeting compound
