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The trend is real but we cannot point to one proven reason

P.RangelM.et al (2023)

Note that in addition to canonical (barrier-related) functions, zonulin and occludin have other key, noncanonical functions that allow them namely to regulate epithelial apoptosis and proliferation and to facilitate viral entry (124)

Iron neurochemistry in Alzheimers disease and Parkinsons disease: targets for therapeutics

doi: 10.3390/ph15060742

128 Facilitates the Simultaneous Delivery of Multiple Drugs NDCDS can also co-deliver two or more substances with different physicochemical properties, pharmacological effects, and therapeutic mechanisms through the same vector, 129 including chemotherapy drugs, genes, and other preparations with antitumor activity, 76 thereby enabling the simultaneous delivery of multiple drugs into the tumor, improving anti-tumor efficacy and reducing the emergence of drug resistance