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Description
Keywords: folate, Vitamin B12, methionine, one-carbon metabolism 1

it's a potent non-stimulant small molecule that selectively inhibits Nicotinamide N-methyltransferase (NNMT), an enzyme primarily found in adipose tissue and the liver

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According to recent studies, various tumor cells enhance their Gln usage by increasing the expression of Gln transporters and enzymes involved in metabolism

The Zhang lab used the JamA-C enzymes from jamaicamide BGC to introduce extender units with a terminal alkyne for incorporation into polyketides