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however, the dose required was four times that recommended and was associated with adverse cardiac side effects (230)

Recall from Equation 16.15 that the ionization constant for a weak acid is as follows: If [HA] = [A ], this reduces to K a = [H 3 O + ]

changes due to applied pressure

doi: 10.3390/cells10123581 128 NelJGDurandtCTheronAJTintingerGRPoolRRichardsGAet al

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