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New pigmented lesions appearing after age 60 warrant heightened suspicion

Biochimica et Biophysica Acta - Mol Cell Biol Lipids

Rao A, Briskey D, Dos Reis C, Mallard AR

confirmed that overexpressed SLC1A3 in gastric cancer activates the PI3K/AKT pathway, upregulates the expression levels of Glucose transporter 1 (GLUT1), Hexokinase 2 (HK2), and Lactate dehydrogenase A (LDHA), and promotes the growth of gastric cancer, while treatment with the PI3K/AKT inhibitor LY294002 could inhibit the growth-promoting effect of SLC1A3 overexpression on gastric cancer

In line with this, the crucial roles of acyl chain-specific sphingolipids and their respective molecular mechanisms have been uncovered in diverse biological processes 4,5