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Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study

Parrondo RD, Gardner LB, Alhaj Moustafa M, et al

Many people lose weight and end up looking smaller but not leaner, weaker instead of stronger, or more exhausted than they expected

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Methimazole, an oral antithyroid medication which is a potent peroxidase and tyrosinase inhibitor, has shown depigmentation effects when applied topically and caused significant skin lightening in patients with melasma [75, 78, 96, 97]

However, these direct and indirect approaches, referred to as BDNF-based therapies, still face many other challenges