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New York: Academic Press, 1992: 2136 Harper P, Wadstrom C, Cederblad G

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2 Materials and methods 2.1 Animal experiment and sampling The study was conducted at the experimental station of the Institute of Animal Nutrition, Friedrich-Loeffler-Institut (FLI), located in Braunschweig, Germany, in full compliance with the German Animal Welfare Act and approved by the Lower Saxony State Office for Consumer Protection and Food Safety (LAVES, Oldenburg, Germany) (AZ33.19-42502-04-16/2378)

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A potential unifying feature that enhances susceptibility among those with each of these conditions is an elevation in systemic inflammation, which leads to a greater viral load with the potential for a cytokine storm and increased mortality 3

Rafraf et al., 2012[39]