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Study Design and Heterogeneity Differences in study design and patient populations further contribute to inconsistent findings

These patients are not subject to hemolytic crises after exposure to oxidants and their RBCs do not have any characteristic morphologic abnormalities

Figure S3: Vitamin B12 deficiency may cause or be associated with signs and symptoms in multiple organ systems

Ir Med J 2005;98(4): 105-7

Of interest, early-life exposure to riboflavin-producing commensals has been shown to promote the correct development of the gut and skin MAIT cell response in germ-free murine neonates primed with a synthetic early-life gut microbial community consisting of two Lactobacillaceae , two Enterobacteriaceae and Enterococcus faecalis and the skin commensal Staphylococcus epidermidis, respectively 200,201

Treatment may not be suitable for: Pregnancy or breastfeeding Certain medical conditions (assessed during consultation) Current chemotherapy treatment Severe kidney or liver disease How Often Should I Get Treatments