glutathione scavenger in kyrgyz Identification of cytotoxic, glutathione-reactive moieties inducing accumulation of reactive oxygen species via depletion The Glutathione System: A Journey
Description
GPx5, GPx7, and GPx8 lack selenocysteine and instead use cysteine (CysGPxs)
Disruption of this coordination, whether through mitochondrial dysfunction leading to decreased CPT1 activity or insufficient substrate supply for FAO, can cause energy imbalance in the myocardium
Image credit: Promega Measure Metabolic Changes in Cancer and Adipocyte Cell Lines MCF7 Cancer Cells In the cancer model, when cells are oxygen-starved, the hypoxic conditions shift cellular metabolism from oxidative phosphorylation to glycolysis
Gasowska-Bajger, B
10.1523/JNEUROSCI.1645-05.2005 44 CaiZ.YanL.-J
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