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The Ecuadorian Laron and Brazilian Itabaianinha cohorts with congenital mutations in the GH and GHRH receptors, respectively, both provide a unique and arguably the purest examples to evaluate the effects of chronic severe IGF-I and both severe GH and IGF-I deficiency, respectively, with severe hypoinsulinemia being the common denominator in both cohorts (151, 152) ( Table 1

doi: 10.1111/wrr.12387

The positive influence of Nigella sativa as an immunomodulator (with its ingredientthymoquinone) on thyroid function also should be shortly mention here [118]

The following stacking strategies are based on mechanistic logic and the available evidence base, though human clinical trials of specific combinations remain limited
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doi:10.1007/978-3-319-78957-6 313
