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doi: 10.1186/s13395-018-0150-5

Dose-finding studies for CNS effects in humans are needed because extrapolation from rat doses is unreliable

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Melatonin supplementation alone, though, wasnt enough to return the AD mice to normal control levels, but the improvements were significant.[ref][ref][ref][ref] Another study using a mouse model of AD found that melatonin reduced the signs of Alzheimers, including cognitive deficits