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In addition, the mRNA level of GPX1 and enzyme activity of total GPX in blood were lower in the KBD group than they were in the control group 67

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This enhanced clearance prevents the toxic buildup of mediators that drive systemic symptoms

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This leads to a form of cerebral folate deficiency (CFD) , where the brain has low levels of 5-methyltetrahydrofolate (5-MTHF) , the active folate form crucial for neurotransmitter synthesis, DNA methylation, and myelin formation