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GI Mucosal Integrity: Maintains and protects the gastrointestinal lining

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(2001) Effect of synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) on melatonin secretion by the pineal gland of young and old rats [PMID: 11335898, Anisimov VN et al

Pepsin operates at gastric pH of roughly 1.5 to 3.5 and preferentially cleaves aromatic and hydrophobic residue bonds