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First, the heat makes collagen immediately contract and tighten up

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A major limitation, however, lies in the fact that many of the previous research relies primarily on animal models that do not fully recapitulate the complexity, heterogeneity, and comorbidities of human intestinal I/R injury, thereby limiting the predictive value for patient outcomes

doi: 10.1111/nph.16777 159 ZhuH.HuH

When cells are damaged due to DNA damage, shortened telomeres, genomic instability, or oncogenic mutations, they can either progress to their apoptotic or senescence stage to suppress tumor development [186]

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