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3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

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Like QueD/QueD2, both FolEIA and FolEIB are members of the T-fold superfamily, 678 and are characterized by very low pairwise sequence identity and distinct oligomeric assembly states, i.e , dimer of pentamers vs a dimer of dimers double ring-shaped architectures in FolEIA and FolEIB, respectively (Figure 30A,B)

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Furthermore, methylene blue induced a dose and time dependent generation of superoxide anion from rabbit pulmonary arterial smooth muscle cells, as evidenced from spectrophotometric determination of cytochrome c reduction