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Historically, the covalent C-Co bond is one of first examples of carbon-metal bonds to be discovered in biology

However, as it assumes that the entire system is at a steady state, a simple MFA cannot simulate any temporal changes in metabolite concentrations

This perspective takes a look back at the significance of this work in building knowledge about this area of antioxidant metabolism in plants and some of the developments in the field since

513 Cardiovascular dysfunction is one important fetal defect brought about by prenatal hypoxia, which may lead to fetal growth restriction and even death
