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Impairments in the ETC can lead to electron leakage and the excessive generation of reactive oxygen species (ROS)

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Through the activity of the estrobolome, specific gut bacteriaparticularly those producing -glucuronidase such as Clostridia can deconjugate estrogen in the intestine, thereby enhancing enterohepatic recirculation and increasing systemic estrogen levels [2]

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Adequate maternal pyridoxine levels are important for fetal development, and the vitamin is present in prenatal vitamins in amounts roughly equivalent to the Recommended Dietary Allowance (around 1.9 mg per day for pregnant women)

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