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Ca 2+ overload activates calpain, a cysteine protease that degrades the cytoskeleton [91]

Ou SI, Govindan R, Eaton KD, Otterson GA, Gutierrez ME, Mita AC, et al

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Cyt c released from mitochondria binds Apoptotic protease activating factor-1 (APAF-1) and subsequently activates caspase-9 [117] to trigger apoptosis [118,119,120] (Fig