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In support of this paradigm, mucosa-adherent bacteria in PSC have been shown to be distinct from those found in patients with IBD alone and normal, healthy colon.14 ,4346 Taken together with our previously published data, we hypothesise that VAP-1 expression is critical during multiple stages of PSC pathogenesis

Thats why there are treatment options to help patients dealing with this disorder

With selective effect on both epithelial and even more endothelial tissue damage (maintaining both epithelial and endothelial integrity), it was very safe, and there were no side effects in clinical trials (i.e., used in ulcerative colitis)

[DOI] [PubMed] [Google Scholar] 11.Stancic-Rokotov D, Slobodnjak Z, Aralica J, et al

279(3):E501 to 507

Interestingly, the microbes deamidate NAM into NA, therefore bypassing salvage